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The combined pill also stops the ovaries from releasing an egg so most women will not ovulate. Sildenafil is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41 range 25 to 63. Co administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state with sildenafil resulted in a 140 increase in sildenafil Cmax and a 210 increase in sildenafil AUC. Sildenafil 100, like other doses of the medication, takes four hours after ingestion to lessen its potency by half.

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