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Accordingly, caution is necessary for patients already on ritonavir when prescribing sildenafil. Istradefyllineistradefylline will increase the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism. It can be an embarrassing and frustrating condition for many men, but luckily, erectile dysfunction treatments are available to help. While you are more likely to suffer with ED as you get older, it is your attitude not your age that is the biggest barrier in treating the condition.

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