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A stronger CYP3A4 inhibitor such as ketoconazole or itraconazole could be expected to have greater effect than that seen with saquinavir. Several studies have also indicated the drug may be effective in improving libido and arousal in women taking selective serotonin uptake inhibitors. Sildenafil is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41 range 25 to 63. Sertraline and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed.

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