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Other conditions that can lead to diarrhea are cancer, dehydration, diarrhea due to chemotherapy, pregnancy, anesthesia, surgery and chemotherapy. The coadministration of sildenafil and ritonavir increased plasma sildenafil concentration due to CYP 3A4 2C9 inhibition. Tucatinib will increase the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism.

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