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Hormone induced ED Hormonal abnormalities, such as increased prolactin , steroid abuse by bodybuilders, too much or too little thyroid hormone, and hormones administered for prostate cancer may cause ED. These vasoactive agents include prostaglandin E1, papaverine and phentolamine , which work alone or in combination to elicit an erection. The overall appearance of the glans penis in men also varies by whether or not they have been circumcised.

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