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The situation is a testament to the largely unregulated nature of the 45 billion a year US supplement industry. One of the most important steps we took was to consult a few medical practitioners before incorporating any brand into our list. Itraconazoleitraconazole will increase the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism. In as little as four minutes after dosing, the DehydraTECH formulation delivered 74 more sildenafil into the bloodstream on average than the concentration matched, generic control formulation.

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