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Rather, each medication has particular advantages and disadvantages that are important to understand when selecting the treatment that is best for you. Try at least two different oral agents before moving on to other therapy. Check a serum, morning testosterone level in all men who fail oral PDE 5 therapy. This underscores the importance of discussing all medication changes and supplements you are taking with a healthcare professional. Gums that are swollen, painful, or bleed when you brush or floss are likely signs of gum disease.